The spread of multidrug-resistant (MDR) bacteria is a global public health crisis. Bacteriophage therapy (or “phage therapy”) constitutes a potential alternative approach to treat MDR infections. We are working on multiple projects to develop quantitative models to account for the system-level interactions between bacteria, phage, and antibiotics. Ongoing projects include:

• Immunophage synergy and tripartite dynamics arising from interactions between MDR pathogens, phage, and the innate immune system.
• Models of combination phage and antibiotic therapy
• Phage interactions with bacterial biofilms

Recent Publications

• Metapopulation model of phage therapy of an acute Pseudomonas aeruginosa lung infection
• Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy
• Inferring strain-level mutational drivers of phage-bacteria interaction phenotypes

Team members